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Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs: possible implications for its antihypertensive effect. Hypertension ; 41 : —9. Effect of sesamin on the protein expression of p22 phox in aortas. These results were consistent with previous reports 64 , J Am Soc Hypertens ; 1 : 30— Protection against development and maintenance of hypertension in stroke-prone spontaneously hypertensive rats. Treatment of SHRs with sesamin increased both the endothelium-dependent and endothelium-independent relaxation of aortic rings in a dose-dependent manner. NO has opposing, dose-dependent effects on endothelial cell apoptosis; low concentrations of NO protect endothelial cells from apoptosis-inducing stimuli and high concentrations of NO can induce apoptosis 42 , Voluntary physical exercise-induced vascular effects in spontaneously hypertensive rats.


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Enhanced NO inactivation and hypertension induced by a high-fat, refined-carbohydrate diet. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Evidence that p47 phox may participate in forming this oxidase in vitro and in vivo.

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Treatment of SHRs with sesamin increased both the endothelium-dependent and endothelium-independent relaxation of aortic rings in a dose-dependent manner. Gen Physiol Biophys ; 24 : — Results: The aortic rings of SHRs showed significantly smaller ACh-induced and nitroprusside-induced relaxation than those of control rats.

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Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Hydroethidine microfluorography. The abnormal expression of p22 phox , p47 phox , and eNOS were reversed by treatment with sesamin for 16 weeks Figure How the descriptions of four eyewitness journalists, who were 'embedded' in the mission to capture Ned Kelly, would frame the subsequent retellings of the story.

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Nitric oxide induces and inhibits apoptosis through different pathways. Effect of sesamin on the protein expression of p22 phox in aortas. The journalists who framed Ned Kelly's legend How the descriptions of four eyewitness journalists, who were 'embedded' in the mission to capture Ned Kelly, would frame the subsequent retellings of the story. Full browser? Reactive oxygen species in vascular biology: implications in hypertension. Received : 06 September Review: A White, White Day is a slow burning thriller with an explosive end An alpha-male cop struggles to make sense of his wife's death and their frayed marriage in this unsettling Icelandic drama.

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Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Treatment of SHRs with sesamin increased both the endothelium-dependent and endothelium-independent relaxation of aortic rings in a dose-dependent manner. Ultimately, these findings demonstrated that sesamin improved arterial function, which may be attributed to decreased p22 phox and p47 phox expression and increased eNOS expression.

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